Digital outcome measures are associated with brain atrophy in patients with multiple sclerosis.

ABSTRACT:

Background

Digital monitoring of people with multiple sclerosis (PwMS) using smartphone-based monitoring tools is a promising method to assess disease activity and progression.

Objective

To study cross-sectional and longitudinal associations between active and passive digital monitoring parameters and MRI volume measures in PwMS.

Methods

In this prospective study, 92 PwMS were included. Clinical tests [Expanded Disability Status Scale (EDSS), Timed 25 Foot Walk test (T25FW), 9-Hole Peg Test (NHPT), and Symbol Digit Modalities Test (SDMT)] and structural MRI scans were performed at baseline (M0) and 12-month follow-up (M12). Active monitoring included the smartphone-based Symbol Digit Modalities Test (sSDMT) and 2 Minute Walk Test (s2MWT), while passive monitoring was

SUBMITTER: Molenaar PCG 

PROVIDER: S-EPMC11377687 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature