Glioblastoma mesenchymal subtype enhances antioxidant defence to reduce susceptibility to ferroptosis.

ABSTRACT: Glioblastoma (GBM) represents an aggressive brain tumor, characterized by intra- and inter-tumoral heterogeneity and therapy resistance, leading to unfavourable prognosis. An increasing number of studies pays attention on the regulation of ferroptosis, an iron-dependent cell death, as a strategy to reverse drug resistance in cancer. However, the debate on whether this strategy may have important implications for the treatment of GBM is still ongoing. In the present study, we used ferric ammonium citrate and erastin to evaluate ferroptosis induction effects on two human GBM cell lines, U-251 MG, with proneural characteristics, and T98-G, with a mesenchymal profile. The response to ferroptosis induction was markedly different between cell lines, indeed T98-G cells showed an enhanced antioxid

SUBMITTER: D'Aprile S 

PROVIDER: S-EPMC11377710 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature