Tumor-derived DEFB1 induces immune tolerance by inhibiting maturation of dendritic cell and impairing CD8+ T cell function in esophageal squamous cell carcinoma.

ABSTRACT:

Objective

CD8+ T cells are the key effector cells in the anti-tumor immune response. The mechanism underlying the infiltration of CD8+ T cells in esophageal squamous cell carcinoma (ESCC) has not been clearly elucidated.

Methods

Fresh ESCC tissues were collected and grouped according to the infiltration density of CD8+ T cells. After the transcriptome sequencing on these samples and the combined analyses with The Cancer Genome Atlas (TCGA) ESCC data, a secreted protein DEFB1 was selected to explore its potential role in the infiltration of CD8+ T cells. Bioinformatics analyses, histological verification and in vitro experiments were then performed.

Results

DEFB1 was highly expressed in ESCC, and the high expression of DEFB1 was an independent risk factor for ov

SUBMITTER: Duan J 

PROVIDER: S-EPMC11377887 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature