Upper Gastrointestinal Mucosal Damage and Subsequent Risk of Parkinson Disease.

ABSTRACT:

Importance

The gut-first hypothesis of Parkinson disease (PD) has gained traction, yet potential inciting events triggering Parkinson pathology from gut-related factors remain unclear. While Helicobacter pylori infection is linked to mucosal damage (MD) and PD, it is unknown how upper gastrointestinal MD from any source increases PD risk.

Objective

To evaluate any association between upper endoscopy findings of MD and subsequent clinical PD diagnosis.

Design, setting, and participants

This was a retrospective cohort study of patients with no PD history undergoing upper endoscopy with biopsy between January 2000 and December 2005, with final follow-up assessments completed July 31, 2023. The study was conducted within the Mass General Brigham system, a multicenter netw

SUBMITTER: Chang JJ 

PROVIDER: S-EPMC11378005 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature