Circulating Tumor DNA and Survival in Metastatic Breast Cancer: A Systematic Review and Meta-Analysis.

ABSTRACT:

Importance

Metastatic breast cancer (MBC) poses a substantial clinical challenge despite advancements in diagnosis and treatment. While tissue biopsies offer a static snapshot of disease, liquid biopsy-through detection of circulating tumor DNA (ctDNA)-provides minimally invasive, real-time insight into tumor biology.

Objective

To determine the association between ctDNA and survival outcomes in patients with MBC.

Data sources

An electronic search was performed in 5 databases (CINAHL, Cochrane Library, Embase, Medline, and Web of Science) and included all articles published from inception until October 23, 2023.

Study selection

To be included in the meta-analysis, studies had to (1) include women diagnosed with MBC; (2) report baseline plasma ctDNA data; and (3)

SUBMITTER: Dickinson K 

PROVIDER: S-EPMC11378006 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature