A refactored biosynthetic pathway for the production of glycosylated microbial sunscreens.

ABSTRACT: Mycosporine-like amino acids (MAAs) are a family of water-soluble and colorless secondary metabolites, with high extinction coefficients, that function as microbial sunscreens. MAAs share a cyclohexinimine chromophore that is diversified through amino acid substitutions and attachment of sugar moieties. The genetic and enzymatic bases for the chemical diversity of MAAs remain largely unexplored. Here we report a series of structurally distinct MAAs and evidence for an unusual branched biosynthetic pathway from a cyanobacterium isolated from lake sediment. We used a combination of high-resolution liquid chromatography-mass spectrometry (HR-LCMS) analysis and nuclear magnetic resonance (NMR) spectroscopy to identify diglycosylated-palythine-Ser (C₂₂H₃₆N₂O

SUBMITTER: Arsın S 

PROVIDER: S-EPMC11378024 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature