NMR metabolomics-guided DNA methylation mortality predictors.

ABSTRACT:

Background

¹H-NMR metabolomics and DNA methylation in blood are widely known biomarkers predicting age-related physiological decline and mortality yet exert mutually independent mortality and frailty signals.

Methods

Leveraging multi-omics data in four Dutch population studies (N = 5238, ∼40% of which male) we investigated whether the mortality signal captured by ¹H-NMR metabolomics could guide the construction of DNA methylation-based mortality predictors.

Findings

We trained DNA methylation-based surrogates for 64 metabolomic analytes and found that analytes marking inflammation, fluid balance, or HDL/VLDL metabolism could be accurately reconstructed using DNA-methylation assays. Interestingly, a previously reported multi-analyte score indicati

SUBMITTER: Bizzarri D 

PROVIDER: S-EPMC11378104 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature