Genetic landscape of homologous recombination repair and practical outcomes of PARPi therapy in ovarian cancer management.

ABSTRACT:

Background

Genetic studies of ovarian cancer (OC) have historically focused on BRCA1/2 mutations, lacking other studies of homologous recombination repair (HRR). Poly (ADP-ribose) polymerase inhibitors (PARPi) exploit synthetic lethality to significantly improve OC treatment outcomes, especially in BRCA1/2 deficiency patients.

Objectives

Our study aims to construct a mutation map of HRR genes in OC and identify factors influencing the efficacy of PARPi.

Design

A retrospective observational analysis of HRR gene variation data from 695 OC patients from March 2019 to February 2022 was performed.

Methods

The HRR gene variation data of 695 OC patients who underwent next-generation sequencing (NGS) in the First Affiliated Hospital of Zhengzhou University were retrosp

SUBMITTER: Chen M 

PROVIDER: S-EPMC11378221 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature