Epidemiology of Pediatric Astrovirus Gastroenteritis in a Nicaraguan Birth Cohort.

ABSTRACT:

Background

Astrovirus is a leading cause of acute gastroenteritis in children worldwide. However, few prospective studies have analyzed astrovirus in community-dwelling pediatric populations in low- and middle-income countries.

Methods

We assessed the incidence, risk factors, clinical characteristics, genotypes, viral coinfections, and time distribution of astrovirus gastroenteritis in 443 healthy Nicaraguan children born in 2017 to 2018 who were followed for 36 months. Children were recruited from hospitals and birth records in an economically diverse neighborhood of León city. Astrovirus-positive episodes and genotypes were identified from stool with reverse transcription quantitative polymerase chain reaction and Sanger sequencing.

Results

Of 1708 total specimens t

SUBMITTER: Rubinstein RJ 

PROVIDER: S-EPMC11378399 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature