Unraveling the key role of chromatin structure in cancer development through epigenetic landscape characterization of oral cancer.

ABSTRACT: Epigenetic alterations, such as those in chromatin structure and DNA methylation, have been extensively studied in a number of tumor types. But oral cancer, particularly oral adenocarcinoma, has received far less attention. Here, we combined laser-capture microdissection and muti-omics mini-bulk sequencing to systematically characterize the epigenetic landscape of oral cancer, including chromatin architecture, DNA methylation, H3K27me3 modification, and gene expression. In carcinogenesis, tumor cells exhibit reorganized chromatin spatial structures, including compromised compartment structures and altered gene-gene interaction networks. Notably, some structural alterations are observed in phenotypically non-malignant paracancerous but not in normal cells. We developed transformer models to

SUBMITTER: Xue Y 

PROVIDER: S-EPMC11378415 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature