Brain growth until adolescence after a neonatal focal injury: sex related differences beyond lesion effect.

ABSTRACT:

Introduction

Early focal brain injuries lead to long-term disabilities with frequent cognitive impairments, suggesting global dysfunction beyond the lesion. While plasticity of the immature brain promotes better learning, outcome variability across individuals is multifactorial. Males are more vulnerable to early injuries and neurodevelopmental disorders than females, but long-term sex differences in brain growth after an early focal lesion have not been described yet. With this MRI longitudinal morphometry study of brain development after a Neonatal Arterial Ischemic Stroke (NAIS), we searched for differences between males and females in the trajectories of ipsi- and contralesional gray matter growth in childhood and adolescence, while accounting for lesion characteristics.

Met

SUBMITTER: Postic PY 

PROVIDER: S-EPMC11378422 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature