Factors related to elevated serum immunoglobulin G4 (IgG4) levels in a Japanese general population.

ABSTRACT:

Background

Elevated serum immunoglobulin G4 (IgG4) concentrations are one of the characteristic findings in IgG4-related disease (IgG4-RD). This study investigated the frequency of elevated serum IgG4 levels and associated factors in a general Japanese population.

Methods

Serum IgG4 concentrations were measured in 1,201 residents of Ishikawa prefecture who underwent general medical examinations. Factors associated with elevated serum IgG4 concentrations were assessed by logistic regression analysis. Participants with elevated serum IgG4 were subjected to secondary examinations.

Results

The mean serum IgG4 concentration was 44 mg/dL, with 42 (3.5%) participants having elevated serum IgG4 levels. Age- and sex-adjusted logistic regression analyses showed that male sex, o

SUBMITTER: Tsuge S 

PROVIDER: S-EPMC11378454 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature