Glucocorticoid treatment increases cholesterol availability during critical illness: effect on adrenal and muscle function.

ABSTRACT:

Background

Hypocholesterolemia hallmarks critical illness though the underlying pathophysiology is incompletely understood. As low circulating cholesterol levels could partly be due to an increased conversion to cortisol/corticosterone, we hypothesized that glucocorticoid treatment, via reduced de novo adrenal cortisol/corticosterone synthesis, might improve cholesterol availability and as such affect adrenal gland and skeletal muscle function.

Methods

In a matched set of prolonged critically ill patients (n = 324) included in the EPaNIC RCT, a secondary analysis was performed to assess the association between glucocorticoid treatment and plasma cholesterol from ICU admission to day five. Next, in a mouse model of cecal ligation and puncture-induced sepsis, septic mice were

SUBMITTER: De Bruyn L 

PROVIDER: S-EPMC11378467 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature