Liver kinase B1 (LKB1) regulates the epigenetic landscape of mouse pancreatic beta cells.

ABSTRACT: Liver kinase B1 (LKB1/STK11) is an important regulator of pancreatic β-cell identity and function. Elimination of Lkb1 from the β-cell results in improved glucose-stimulated insulin secretion and is accompanied by profound changes in gene expression, including the upregulation of several neuronal genes. The mechanisms through which LKB1 controls gene expression are, at present, poorly understood. Here, we explore the impact of β cell-selective deletion of Lkb1 on chromatin accessibility in mouse pancreatic islets. To characterize the role of LKB1 in the regulation of gene expression at the transcriptional level, we combine these data with a map of islet active transcription start sites and histone marks. We demonstrate that LKB1 elimination from β-cells results in widespread changes in chr

SUBMITTER: Haberman N 

PROVIDER: S-EPMC11378476 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature