A nanoscale visual exploration of the pathogenic effects of bacterial extracellular vesicles on host cells.

ABSTRACT:

Background

Bacterial extracellular vesicles (EVs) are pivotal mediators of intercellular communication and influence host cell biology, thereby contributing to the pathogenesis of infections. Despite their significance, the precise effects of bacterial EVs on the host cells remain poorly understood. This study aimed to elucidate ultrastructural changes in host cells upon infection with EVs derived from a pathogenic bacterium, Staphylococcus aureus (S. aureus).

Results

Using super-resolution fluorescence microscopy and high-voltage electron microscopy, we investigated the nanoscale alterations in mitochondria, endoplasmic reticulum (ER), Golgi apparatus, lysosomes, and microtubules of skin cells infected with bacterial EVs. Our results revealed significant mitochondrial fissi

SUBMITTER: Kang M 

PROVIDER: S-EPMC11378492 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature