Simulating combined monoaminergic depletions in a PD animal model through a bio-constrained differential equations system.

ABSTRACT:

Introduction

Historically, Parkinson's Disease (PD) research has focused on the dysfunction of dopamine-producing cells in the substantia nigra pars compacta, which is linked to motor regulation in the basal ganglia. Therapies have mainly aimed at restoring dopamine (DA) levels, showing effectiveness but variable outcomes and side effects. Recent evidence indicates that PD complexity implicates disruptions in DA, noradrenaline (NA), and serotonin (5-HT) systems, which may underlie the variations in therapy effects.

Methods

We present a system-level bio-constrained computational model that comprehensively investigates the dynamic interactions between these neurotransmitter systems. The model was designed to replicate experimental data demonstrating the impact of NA and 5-HT d

SUBMITTER: Carli S 

PROVIDER: S-EPMC11378529 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature