Comprehensive analysis of POLH-AS1 as a prognostic biomarker in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC), a prevalent primary malignant tumor, is notorious for its high mortality rate. Despite advancements in HCC treatment, patient outcomes remain suboptimal. This study endeavors to assess the potential prognostic significance of POLH-AS1 in HCC.

Methods

In this research, we gathered RNA-Seq information from individuals with HCC in The Cancer Genome Atlas (TCGA). We analyzed the levels of POLH-AS1 expression in both HCC cells and tissues using statistical tests. Additionally, we examined various prognostic factors in HCC using advanced methodologies. Furthermore, we employed Spearman's rank correlation analysis to examine the association between POLH-AS1 expression and the tumor's immune microenvironment. Finally, the functional roles o

SUBMITTER: Dong Y 

PROVIDER: S-EPMC11378586 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature