Transmission of tuberculosis in rural Henan, China: a prospective population-based genomic spatial epidemiological study.

ABSTRACT: The incidence of tuberculosis (TB) has declined more slowly in rural than urban areas in China, and data on the patterns of transmission and the high-risk populations in rural areas remains scarce. We conducted a population-based study of culture-positive pulmonary TB patients diagnosed in rural Linzhou City, Henan Province from July 2018 to February 2023. Genomic clusters were defined based on whole-genome sequencing and risk factors for clustering were identified by logistic regression. Transmission events were inferred with phybreak and transmission links were sought through epidemiological investigation of clustered patients. Logistic regression was used to explore the relationship between genomic differences of patient isolates and geographical distances of patient residences. Spatial

SUBMITTER: Quan Z 

PROVIDER: S-EPMC11378662 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature