Cobalt ions-derived nanoenzyme array for endosseous neural network reconstruction and osseointegration.

ABSTRACT: Interactions between bone cells and neurocytes are crucial for endosseous nerve and ensuing bone regeneration. However, absence of neural stem cells in bone makes the innervation of implant osseointegration a major challenge. Herein, a nanorod-like array of sodium hydrogen titanate (ST) co-doped with Co²⁺ and Co³⁺, namely STC_h that behaves as a reactive oxygen species (ROS)-scavenging enzyme, was hydrothermally formed on Ti substrate. We show that the doped Co²⁺ and Co³⁺ locate at TiO₆ octahedral interlayers and within octahedra of STC_h lattice, appearing releasable and un-releasable, respectively, leading to an increase in Co³⁺/Co²⁺ ratio and enzyme activity of the array with immersion. The

SUBMITTER: Cai X 

PROVIDER: S-EPMC11378756 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature