A cuproptosis-related prognostic signature for guiding clinical diagnosis and treatment in uveal melanoma patients.

ABSTRACT:

Background

Cuproptosis, one of the most recently discovered forms of cell death, is induced by the disruption of copper binding to the mitochondrial respiratory acylation components. However, the mechanism underlying cuproptosis in uveal melanoma (UM) has not yet been adequately studied.

Methods

RNA and clinical data were obtained from The Cancer Genome Atlas (TCGA) database. Differentially expressed cuproptosis-related genes were identified by R software. A prognostic signature was constructed by applying LASSO regression and Cox regression models. The associations between the signature and the immune microenvironment, overall survival, and drug sensitivity were studied. In addition, qPCR and Western blotting were performed on UM cells and RPE cell lines to verify the expre

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11378888 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature