Blended nexus molecules promote CO₂ to l-tyrosine conversion.

ABSTRACT: Using CO₂ as the primary feedstock offers the potential for high-value utilization of CO₂ while forging sustainable pathways for producing valuable natural products, such as l-tyrosine. Cascade catalysis is a promising approach but limited by stringent purity demands of nexus molecules. We developed an abiotic/biotic cascade catalysis using blended nexus molecules for l-tyrosine synthesis. Specifically, we begin by constructing a solid-state reactor to reduce CO₂ electrochemically, yielding a mixture of acetic acid and ethanol, which serves as the blended nexus molecules. Subsequently, we use genetic engineering to introduce an ethanol utilization pathway and a tyrosine producing pathway to Escherichia coli to facilitate l-tyrosine production. The et

SUBMITTER: Fan L 

PROVIDER: S-EPMC11378904 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature