Condensin dysfunction is a reproductive isolating barrier in mice.

ABSTRACT: Reproductive isolation occurs when the genomes of two populations accumulate genetic incompatibilities that prevent interbreeding^1,2. Understanding of hybrid incompatibility at the cell biology level is limited, particularly in the case of hybrid female sterility³. Here we find that species divergence in condensin regulation and centromere organization between two mouse species, Mus musculus domesticus and Mus spretus, drives chromosome decondensation and mis-segregation in their F₁ hybrid oocytes, reducing female fertility. The decondensation in hybrid oocytes was especially prominent at pericentromeric major satellites, which are highly abundant at M. m. domesticus centromeres^4-6, leading to species-specific chromosome mis-segregation and egg a

SUBMITTER: El Yakoubi W 

PROVIDER: S-EPMC11379054 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature