A causal relationship between sarcopenia and cognitive impairment: A Mendelian randomization study.

ABSTRACT:

Objective

Sarcopenia and cognitive impairment often coexist in the elderly. In this study, we investigated the causal relationship between sarcopenia-related muscle characteristics and cognitive performance.

Methods

We used linkage disequilibrium score regression (LDSC) and Mendelian Randomization (MR) analyses to estimate genetic correlations and causal relationships between genetically predicted sarcopenia-related muscle traits and cognitive function, as well as cognitive function-based discovery samples and replicated samples. Estimated effect sizes were derived from a fixed-effects meta-analysis.

Results

Our univariate genome-wide association study (GWAS) meta-analysis indicated a causal relationship between appendicular lean mass (ALM) (β = 0.049; 95% confidence

SUBMITTER: Liu H 

PROVIDER: S-EPMC11379137 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature