Maggot extract accelerates skin wound healing of diabetic rats via enhancing STAT3 signaling.

ABSTRACT:

Background

Diabetic skin wound is a complex problem due to the disruption of normal repairing program and lack of effective remedy. Lucilia sericata larvae (maggot) is a folk method to treat chronic skin wound, while its therapeutic effects on that caused by diabetic remains unknown.

Objective

This study aims to investigate the therapeutic effects of maggot extract (M.E.) on diabetic skin wound and its molecular mechanism by establishing the skin wound model of diabetic Sprague Dawley (SD) rats.

Methods

Diabetic model was established by injecting intraperitoneally streptozotocin in SD rats under specific pathogen-free (SPF) conditions. The rat fasting blood glucose values were ≧16.7 mmol/L 72 hours after intraperitoneal streptozotocin (60mg/kg body weight) injection.

SUBMITTER: Wu ML 

PROVIDER: S-EPMC11379160 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature