Increased risk of cardiac arrhythmia in Hailey-Hailey disease patients.

ABSTRACT:

Background

Hailey-Hailey disease (HHD) is a rare autosomal dominant skin disease caused by mutations in the ATP2C1 gene, which encodes the secretory Ca2+/Mn2+-ATPase (SPCA1) pump in the Golgi apparatus. Although ATP2C1 is ubiquitously expressed in the body, possible extracutaneous manifestations of HHD are unknown. However, dysfunction of the Golgi apparatus not specifically coupled to ATP2C1 has been associated with heart disease.

Objective

To investigate the association between HHD and common heart disease in a Swedish, population-based cohort.

Methods

We conducted a population-based cohort study based on a linkage of Swedish nationwide registers to investigate the relationship between HHD and heart disease. We have been granted ethical approval from the Swedish Eth

SUBMITTER: Jebril W 

PROVIDER: S-EPMC11379163 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature