Early moderate prenatal alcohol exposure and maternal diet impact offspring DNA methylation across species.

ABSTRACT: Alcohol consumption in pregnancy can affect genome regulation in the developing offspring but results have been contradictory. We employed a physiologically relevant murine model of short-term moderate prenatal alcohol exposure (PAE) resembling common patterns of alcohol consumption in pregnancy in humans. Early moderate PAE was sufficient to affect site-specific DNA methylation in newborn pups without altering behavioural outcomes in adult littermates. Whole-genome bisulfite sequencing of neonatal brain and liver revealed stochastic influence on DNA methylation that was mostly tissue-specific, with some perturbations likely originating as early as gastrulation. DNA methylation differences were enriched in non-coding genomic regions with regulatory potential indicative of broad effects of

SUBMITTER: Bestry M 

PROVIDER: S-EPMC11379454 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature