The protein domains of vertebrate species in which selection is more effective have greater intrinsic structural disorder.

ABSTRACT: The nearly neutral theory of molecular evolution posits variation among species in the effectiveness of selection. In an idealized model, the census population size determines both this minimum magnitude of the selection coefficient required for deleterious variants to be reliably purged, and the amount of neutral diversity. Empirically, an 'effective population size' is often estimated from the amount of putatively neutral genetic diversity and is assumed to also capture a species' effectiveness of selection. A potentially more direct measure of the effectiveness of selection is the degree to which selection maintains preferred codons. However, past metrics that compare codon bias across species are confounded by among-species variation in %GC content and/or amino acid composition. Here,

SUBMITTER: Weibel CA 

PROVIDER: S-EPMC11379457 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature