MetDecode: methylation-based deconvolution of cell-free DNA for noninvasive multi-cancer typing.

ABSTRACT:

Motivation

Circulating-cell free DNA (cfDNA) is widely explored as a noninvasive biomarker for cancer screening and diagnosis. The ability to decode the cells of origin in cfDNA would provide biological insights into pathophysiological mechanisms, aiding in cancer characterization and directing clinical management and follow-up.

Results

We developed a DNA methylation signature-based deconvolution algorithm, MetDecode, for cancer tissue origin identification. We built a reference atlas exploiting de novo and published whole-genome methylation sequencing data for colorectal, breast, ovarian, and cervical cancer, and blood-cell-derived entities. MetDecode models the contributors absent in the atlas with methylation patterns learnt on-the-fly from the input cfDNA methylation pro

SUBMITTER: Passemiers A 

PROVIDER: S-EPMC11379469 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature