Polygenic risk score adds to a clinical risk score in the prediction of cardiovascular disease in a clinical setting.

ABSTRACT:

Background and aims

A cardiovascular disease polygenic risk score (CVD-PRS) can stratify individuals into different categories of cardiovascular risk, but whether the addition of a CVD-PRS to clinical risk scores improves the identification of individuals at increased risk in a real-world clinical setting is unknown.

Methods

The Genetics and the Vascular Health Check Study (GENVASC) was embedded within the UK National Health Service Health Check (NHSHC) programme which invites individuals between 40-74 years of age without known CVD to attend an assessment in a UK general practice where CVD risk factors are measured and a CVD risk score (QRISK2) is calculated. Between 2012-2020, 44,141 individuals (55.7% females, 15.8% non-white) who attended an NHSHC in 147 participating pr

SUBMITTER: Samani NJ 

PROVIDER: S-EPMC11379490 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature