Potential regulation and prognostic model of colorectal cancer with extracellular matrix genes.

ABSTRACT:

Background

The tumor microenvironment (TME) of colorectal cancer (CRC) mainly comprises immune cells, stromal cells, tumor cells, as well as the extracellular matrix (ECM), which holds a pivotal position. The ECM affects cancer progression, but its regulatory roles and predictive potential in CRC are not fully understood.

Methods

We analyzed transcriptomes from CRC tumors and paired normal tissues to study ECM features. Up-regulated ECM components were examined through functional enrichment analysis, and single-cell sequencing identified cell types producing collagen, regulators, and secreted factors. Transcription factor analysis and cell-cell interaction studies were conducted to identify potential regulators of ECM changes. Additionally, a prognostic model was developed u

SUBMITTER: Yang X 

PROVIDER: S-EPMC11379549 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature