The calcium-sensing-receptor (CaSR) in adipocytes contributes to sex-differences in the susceptibility to high fat diet induced obesity and atherosclerosis.

ABSTRACT:

Background

Female mice are more resistant to obesogenic effects of a high-fat diet (HFD), compared to male mice. Although the underlying mechanisms are poorly understood, sex hormones seem to play an important role. Interestingly, the activity of the oestrogen receptor-α (ERα) is affected by the calcium-sensing-receptor (CaSR). Therefore, we investigated sex-differences upon diet-induced obesity and the role of adipocyte-specific CaSR herein.

Methods

Adipocyte-specific Casr deficient mice (AdipoqCre⁺Casr^flox) and control mice (Casr^flox) were injected with AAV8-PCSK9 to make them prone to develop atherosclerosis and fed an obesity-inducing diet for 12 weeks.

Findings

Female mice have lower visceral white adipose tissue (vWAT) mass compa

SUBMITTER: Adam S 

PROVIDER: S-EPMC11379552 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature