Association between initial ventilation mode and hospital outcomes for severe congenital diaphragmatic hernia.

ABSTRACT:

Objective

To determine the association between initial delivery room (DR) ventilator (conventional mechanical ventilation [CMV] versus high frequency oscillatory ventilation [HFOV] and hospital outcomes for infants with severe congenital diaphragmatic hernia (CDH).

Study design

Quasi-experimental design before/after introducing a clinical protocol promoting HFOV. The primary outcome was first blood gas parameters. Secondary outcomes included serial blood gas assessments, ECMO, survival, duration of ventilation, and length of hospitalization.

Results

First pH and CO₂ were more favorable in the HFOV group (n = 75) than CMV group (n = 85), median (interquartile range (IQR)) pH 7.18 (7.03, 7.24) vs. 7.05 (6.93, 7.17), adjusted p-value < 0.001; median CO_2</

SUBMITTER: Wild KT 

PROVIDER: S-EPMC11379620 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature