External validation of the IAIHG autoimmune hepatitis response criteria in a multicentric real-world cohort.

ABSTRACT:

Background & aims

The goal of treatment in autoimmune hepatitis (AIH) is induction of remission to prevent the development of liver fibrosis, cirrhosis, and its related complications. Various definitions of treatment response and remission have been used. The International Autoimmune Hepatitis Group (IAIHG) recently defined consensus criteria for treatment response. We aimed to validate the IAIHG response criteria in our cohort and establish correlations with survival endpoints.

Methods

We performed a retrospective, multicentric cohort study in one tertiary and seven secondary care centres in Belgium. Eligible patients were at least 18 years of age at data collection and were diagnosed with AIH by a simplified IAIHG score of ≥6. Complete biochemical response (CBR) was define

SUBMITTER: Grossar L 

PROVIDER: S-EPMC11379665 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature