Prostate cancer subtyping and differential methylation analysis based on the ETS family of transcription factors fusion genes.

ABSTRACT: Prostate cancer (PCa) is a highly heterogeneous disease, encompassing various molecular and clinical pathological subtypes. Fusion genes play a facilitating role in the occurrence and progression of PCa. We categorized PCa samples into the ETS family of transcription factors fusion positive and fusion negative subtypes based on fusion genes. This subtyping method is closely related to the epigenomic DNA methylation profiles of PCa, with each sample cluster including more than 85% of the patients. We conducted an analysis of the distribution of the ETS family fusion genes on chromosomes, fusion modes within reading frames, and predictions of structural domains. Among these, the highest frequency of the ETS family related fusion genes occurred on chromosome 21. Compared to the parental genes

SUBMITTER: Niu W 

PROVIDER: S-EPMC11379718 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature