Extra-islet cells expressing insulin or glucagon in the pancreas of young organ donors.

ABSTRACT:

Aims

The existence of insulin- or glucagon-expressing extra-islet endocrine cells scattered in the pancreas is well-known, but they have been sparsely characterized. The aim of this study was to examine their density, distribution, transcription-factor expression, and mitotic activity in young non-diabetic subjects.

Methods

Multispectral imaging was used to examine PDX1, ARX, Ki67, insulin and glucagon in extra-islet endocrine cells in pancreatic tissue from organ donors aged 1-25 years.

Results

Extra-islet insulin- or glucagon-positive cells were frequent in all donors (median 17.3 and 22.9 cells/mm² respectively), with an insulin:glucagon cell ratio of 0.9. The density was similar regardless of age. PDX1 localized mainly to insulin-, and ARX mainly to glu

SUBMITTER: Granlund L 

PROVIDER: S-EPMC11379743 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature