Insights into the assembly of the neovaginal microbiota in Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome patients.

ABSTRACT: Neovaginas are surgically constructed to correct uterovaginal agenesis in women with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome or as part of gender-affirming surgery for transfeminine individuals. Understanding the assembly of the neovaginal microbiota is crucial for guiding its management. To address this, we conducted a longitudinal study on MRKH patients following laparoscopic peritoneal vaginoplasty. Our findings reveal that the early microbial assemblage exhibited stochastic characteristics, accompanied with a notable bloom of Enterococcus faecalis and genital Mycoplasmas. While both the pre-surgery dimple microbiota and the fecal microbiota constituted the primary species pool, the neovaginal microbiota developed into a microbiota that resembled that of a normal vagina at 6-12 m

SUBMITTER: Chen N 

PROVIDER: S-EPMC11379825 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature