Wide-field calcium imaging of cortical activation and functional connectivity in externally- and internally-driven locomotion.

ABSTRACT: The role of the cerebral cortex in self-initiated versus sensory-driven movements is central to understanding volitional action. Whether the differences in these two movement classes are due to specific cortical areas versus more cortex-wide engagement is debated. Using wide-field Ca²⁺ imaging, we compared neural dynamics during spontaneous and motorized treadmill locomotion, determining the similarities and differences in cortex-wide activation and functional connectivity (FC). During motorized locomotion, the cortex exhibits greater activation globally prior to and during locomotion starting compared to spontaneous and less during steady-state walking, during stopping, and after termination. Both conditions are characterized by FC increases in anterior secondary motor cortex (

SUBMITTER: West SL 

PROVIDER: S-EPMC11379880 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature