Population genomics of Streptococcus mitis in UK and Ireland bloodstream infection and infective endocarditis cases.

ABSTRACT: Streptococcus mitis is a leading cause of infective endocarditis (IE). However, our understanding of the genomic epidemiology and pathogenicity of IE-associated S. mitis is hampered by low IE incidence. Here we use whole genome sequencing of 129 S. mitis bloodstream infection (BSI) isolates collected between 2001-2016 from clinically diagnosed IE cases in the UK to investigate genetic diversity, antimicrobial resistance, and pathogenicity. We show high genetic diversity of IE-associated S. mitis with virtually all isolates belonging to distinct lineages indicating no predominance of specific lineages. Additionally, we find a highly variable distribution of known pneumococcal virulence genes among the isolates, some of which are overrepresented in disease when compared to carriage strains.

SUBMITTER: Kalizang'oma A 

PROVIDER: S-EPMC11379897 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature