Oligodendroglioma patient survival is associated with circulating B-cells and age.

ABSTRACT:

Background

Variations in survival among patients with oligodendroglioma are unexplained by known prognostic factors. To assess the impact of peripheral immune profiles on prognosis, we applied immunomethylomics analyses-DNA methylation of archived whole blood samples, to characterize immune cells.

Methods

We compared the proportions of immune cells from patients with oligodendroglioma to other glioma subtypes and controls. We used recursive partitioning analysis (RPA) within the oligodendrogliomas to correlate with survival.

Results

Patients with oligodendrogliomas (141) were median age at diagnosis of 44 years; 57% male; 75% White; 60% prior chemotherapy; and 25% on dexamethasone at sample collection. Patients with oligodendrogliomas had immune profiles more similar

SUBMITTER: Taylor JW 

PROVIDER: S-EPMC11379917 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature