P450Rdb: A manually curated database of reactions catalyzed by cytochrome P450 enzymes.

ABSTRACT:

Introduction

Cytochrome P450 enzymes (P450s) are recognized as the most versatile catalysts worldwide, playing vital roles in numerous biological metabolism and biosynthesis processes across all kingdoms of life. Despite the vast number of P450 genes available in databases (over 300,000), only a small fraction of them (less than 0.2 %) have undergone functional characterization.

Objectives

To provide a convenient platform with abundant information on P450s and their corresponding reactions, we introduce the P450Rdb database, a manually curated resource compiles literature-supported reactions catalyzed by P450s.

Methods

All the P450s and Reactions were manually curated from the literature and known databases. Subsequently, the P450 reactions organized and categorized a

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11380020 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature