Discovery of new quaternized norharmane dimers as potential anti-MRSA agents.

ABSTRACT:

Introduction

Methicillin-resistant Staphylococcus aureus (MRSA)-caused infections greatly threaten public health. The discovery of natural-product-based anti-MRSA agents for treating infectious diseases has become one of the current research focuses.

Objectives

This study aims to identify promising anti-MRSA agents with a clear mechanism based on natural norharmane modified by quaternization or dimerization.

Methods

A total of 32 norharmane analogues were prepared and characterized. Their antibacterial activities and resistance development propensity were tested by the broth double-dilution method. Cell counting kit-8 and hemolysis experiments were used to assess their biosafety. The plasma stability, bactericidal mode, and biofilm disruption effects were examined by

SUBMITTER: Dai JK 

PROVIDER: S-EPMC11380033 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature