Agreement Between Mega-Trials and Smaller Trials: A Systematic Review and Meta-Research Analysis.

ABSTRACT:

Importance

Mega-trials can provide large-scale evidence on important questions.

Objective

To explore how the results of mega-trials compare with the meta-analysis results of trials with smaller sample sizes.

Data sources

ClinicalTrials.gov was searched for mega-trials until January 2023. PubMed was searched until June 2023 for meta-analyses incorporating the results of the eligible mega-trials.

Study selection

Mega-trials were eligible if they were noncluster nonvaccine randomized clinical trials, had a sample size over 10 000, and had a peer-reviewed meta-analysis publication presenting results for the primary outcome of the mega-trials and/or all-cause mortality.

Data extraction and synthesis

For each selected meta-analysis, we extracted results of sma

SUBMITTER: Kastrati L 

PROVIDER: S-EPMC11380108 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature