Causal effects of gut microbiota on risk of overactive bladder symptoms: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Clinical observations indicate a correlation between the gut microbiota and overactive bladder (OAB) symptoms. Nevertheless, the causal relationship and mechanisms between gut microbiota and OAB symptoms remain elusive.

Methods

Two-sample Mendelian randomization (MR) analyses were performed to assess the association between gut microbiota and OAB symptoms, including urinary incontinence (UI). Data were obtained from the MiBioGen International Consortium genome-wide association studies (GWAS) dataset and the IEU GWAS database. The inverse variance weighted method was used as the primary approach in the MR analysis, with the weighted median, MR-Egger, and weighted mode methods as supplementary approaches. Sensitivity analyses were employed to assess potential violat

SUBMITTER: Shen C 

PROVIDER: S-EPMC11380132 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature