Role of inflammatory cytokines and the gut microbiome in vascular dementia: insights from Mendelian randomization analysis.

ABSTRACT:

Background

Both inflammatory cytokines and the gut microbiome are susceptibility factors for vascular dementia (VaD). The trends in the overall changes in the dynamics of inflammatory cytokines and in the composition of the gut microbiome are influenced by a variety of factors, making it difficult to fully explain the different effects of both on the different subtypes of VaD. Therefore, this Mendelian randomization (MR) study identified the inflammatory cytokines and gut microbiome members that influence the risk of developing VaD and their causal effects, and investigated whether inflammatory cytokines are gut microbiome mediators affecting VaD.

Methods

We obtained pooled genome-wide association study (GWAS) data for 196 gut microbiota and 41 inflammatory cytokines and use

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11380139 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature