HNRNPA2B1 induces cell proliferation and acts as biomarker in breast cancer.

ABSTRACT:

Background

Numerous studies have shown that m6A plays an important regulatory role in the development of tumors. HNRNPA2B1, one of the m6A RNA methylation reading proteins, has been proven to be elevated in human cancers.

Objective

In this study, we aimed to identify the role of HNRNPA2B1 in breast cancer.

Methods

HNRNPA2B1 expression was investigated via RT-qPCR and TCGA database in breast cancer. Then, the function of HNRNPA2B1 on cancer cell was measured by CCK8 assays, colony formation and scratch assays. In addition, HNRNPA2B1 expression in BRCA was explored via the Wilcoxon signed-rank test, KruskalWallis test and logistic regression. The association with HNRNPA2B1 expression and survival were considered by KaplanMeier and Cox regression analyses. The biological

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11380248 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature