Quantitative muscle MRI in sporadic inclusion body myositis (sIBM): A prospective cohort study.

ABSTRACT:

Background

Sporadic inclusion body myositis (sIBM) is the predominant idiopathic inflammatory myopathy (IIM) in older people. Limitations of classical clinical assessments have been discussed as possible explanations for failed clinical trials, underlining the need for more sensitive outcome measures. Quantitative muscle MRI (qMRI) is a promising candidate for evaluating and monitoring sIBM.

Objective

Longitudinal assessment of qMRI in sIBM patients.

Methods

We evaluated fifteen lower extremity muscles of 12 sIBM patients (5 females, mean age 69.6, BMI 27.8) and 12 healthy age- and gender-matched controls. Seven patients and matched controls underwent a follow-up evaluation after one year. Clinical assessment included testing for muscle strength with Quick Motor Funct

SUBMITTER: Schlaffke L 

PROVIDER: S-EPMC11380292 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature