First hip hemiarthroplasty in a Gottingen Minipig; surgical and post-mortem protocol.

ABSTRACT:

Background

Prosthetic joint infections (PJI) are recalcitrant, hard-to-treat infections and severe complications of joint arthroplasty. Therefore, there is a need to develop new effective treatment strategies, and animal models of high clinical relevance are needed. This study aimed to develop a detailed surgical protocol for hip hemiarthroplasty in Göttingen minipigs and a thorough post-mortem sampling protocol to pave the way for creating a minipig PJI model.

Methods

Three adult female Göttingen minipigs underwent surgery with insertion of a hip hemiarthroplasty, using the anterior approach to the hip joint. After surgery the minipigs were followed closely with daily clinical evaluation and gait scoring. Comprehensive post-mortem analyses were performed with evaluation of

SUBMITTER: Hartmann KT 

PROVIDER: S-EPMC11380332 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature