First trimester maternal serum PAPP-A and free β-hCG levels and risk of SGA or LGA in women with and without GDM.

ABSTRACT:

Background

Maternal gestational diabetes (GDM), small (SGA) and large (LGA) for gestational age neonates are associated with increased morbidity in both mother and child. We studied how different levels of first trimester pregnancy associated plasma protein-A (PAPP-A) and free beta human chorionic gonadotropin (fβ-hCG) were associated with SGA and LGA in GDM pregnancies and controls.

Methods

Altogether 23 482 women with singleton pregnancies participated in first trimester combined screening and delivered between 2014 and 2018 in Northern Finland and were included in this retrospective case-control study. Women with GDM (n = 4697) and controls without GDM (n = 18 492) were divided into groups below 5th and 10th or above 90th and 95th percentile (pc) PAPP-A and fβ-hCG MoM lev

SUBMITTER: Kantomaa T 

PROVIDER: S-EPMC11380344 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature