Mitigation of synaptic and memory impairments via F-actin stabilization in Alzheimer's disease.

ABSTRACT:

Background

Synaptic dysfunction, characterized by synapse loss and structural alterations, emerges as a prominent correlate of cognitive decline in Alzheimer's disease (AD). Actin cytoskeleton, which serves as the structural backbone of synaptic architecture, is observed to be lost from synapses in AD. Actin cytoskeleton loss compromises synaptic integrity, affecting glutamatergic receptor levels, neurotransmission, and synaptic strength. Understanding these molecular changes is crucial for developing interventions targeting synaptic dysfunction, potentially mitigating cognitive decline in AD.

Methods

In this study, we investigated the synaptic actin interactome using mass spectrometry in a mouse model of AD, APP/PS1. Our objective was to explore how alterations in synaptic

SUBMITTER: P A H 

PROVIDER: S-EPMC11380428 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature