The Essential Role of Angiogenesis in Adenosine 2A Receptor Deficiency-mediated Impairment of Wound Healing Involving c-Ski via the ERK/CREB Pathways.

ABSTRACT: Adenosine receptor-mediated signaling, especially adenosine A_2A receptor (A_2AR) signaling, has been implicated in wound healing. However, the role of endothelial cells (ECs) in A_2AR-mediated wound healing and the mechanism underlying this effect are still unclear. Here, we showed that the expression of A_2AR substantially increased after wounding and was especially prominent in granulation tissue. The delaying effects of A_2AR knockout (KO) on wound healing are due mainly to the effect of A_2AR on endothelial cells, as shown with A_2AR-KO and EC-A_2AR-KO mice. Moreover, the expression of c-Ski, which is especially prominent in CD31-positive cells in granulation tissue, increased after wounding and was decrea

SUBMITTER: Peng Y 

PROVIDER: S-EPMC11380447 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature